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| In this paper, the first description of neurological symptoms in patients with fluorosis has hinted the neurotoxic potential of fluoride. The increasing number of epidemiological studies on fluoride neurotoxicity, especially on children's intelligence, provided evidence for the link between fluoride exposure and nervous system impairment. Meanwhile, the animal behavioral tests by various methods showed that fluoride not only affected spontaneous behaviors, but also impaired the learning and memory ability. Fluoride detected in brain indicated its ability to penetrate the blood-brain barrier. Accumulation of fluoride in brain resulted in biochemical and functional changes in the nervous system. In order to present the understanding process of fluoride neurotoxicity, this review summarize investigations from our and others groups which mainly focus on the effect of fluoride on the nervous system. |
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| Keywords:Clinical Veterinary; fluoride; neurotoxicity |
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