Numerical simulation on the dynamics and oxygen uptake of red blood cells

Zhijun Tan; P.G. Jayathilake

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Numerical simulation on the dynamics and oxygen uptake of red blood cells

Zhijun Tan 1 *,P.G. Jayathilake 2

1.School of Mathematics and Computational Science, Sun Yat-sen University, Guangzhou 510275

2.Department of Mechanical Engineering, National University of Singapore, Singapore 119260

*Correspondence author

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Funding: the PSTNS of Zhu Jiang in Guangzhou city （No.2011J2200099）, The Specialized Research Fund for the Doctoral Program of Higher Education （No.No. 20110171120048）, the Fundamental Research Funds for the Central Universities （No.13lgzd07）

Opened online:18 November 2014

Accepted by: none

Citation: Zhijun Tan,P.G. Jayathilake.Numerical simulation on the dynamics and oxygen uptake of red blood cells[OL]. [18 November 2014] http://en.paper.edu.cn/en_releasepaper/content/4618192

Red blood cells (RBCs) are very important due to their role of oxygen transport from lungs. As the malaria parasite grows in the malaria-infected red blood cells (IRBCs), the properties of the cells change. In the present work, the oxygen uptake by RBCs and IRBCs at the pulmonary capillaries is simulated using a numerical technique based on the two-dimensional immersed interface method. The results for the oxygen uptake by a stationary single RBC have fair agreements with the previously reported results. The numerical results show that the malaria infection could significantly cause deterioration on the oxygen uptake by red blood cells. The results also suggest that the oxygen uptake by individual stationary RBC/IRBC would not be significantly affected by the neighboring cells provided the separation distance is about the dimension of the cell. ?????

Keywords:Red Blood Cell; Malaria; Oxygen; Biomechanics; Numerical simulation?????

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