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Histamine elicits neuronal excitatory response of red nucleus in the rat via H2 receptors in vitro
Chen Kun,Zhu Jingning,Li Hongzhao,Wang Jianjun
Department of Biological Science and Technology, Nanjing University
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Funding: 国家自然科学基金、教育部博士点基金等(No.20010284021)
Opened online:15 March 2004
Accepted by: none
Citation: Chen Kun,Zhu Jingning,Li Hongzhao.Histamine elicits neuronal excitatory response of red nucleus in the rat via H2 receptors in vitro[OL]. [15 March 2004] http://en.paper.edu.cn/en_releasepaper/content/462
 
 
erfusing slices with histamine (1-100 μM) produced the rat rubral neurons an excitatory response (118/132, 89.4%). The histamine-induced excitation was not blocked by the low-Ca2+/high-Mg2+ medium (n=10), supporting a direct postsynaptic action of the amine. Histamine H2 receptor antagonist ranitidine effectively blocked the excitatory response of rubral neurons to histamine (n=26), but H1 receptor antagonist triprolidine did not (n=24). The excitatory effect of histamine could be mimicked by dimaprit, a highly selective H2 receptor agonist (n=24), and the dimaprit-elicited excitation of the rubral neurons could be blocked by ranitidine (n=16), but not by triprolidine (n=9). In addition, H1 receptor agonist 2-pyridylethylamine could not elicit rubral neurons any response (n=12). These results indicate that histamine excites RN neurons through H2 receptors and suggest that the histaminergic afferent fibers may play an important functional role in the sensorimotor integration through th
Keywords:Red nucleus; Histamine; Histamine receptors; Hypothalamo-rubral fibers
 
 
 

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