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Xylocarpin H, a component of Xylocarpus granatum, produces antidepressant-like activities in mice
YIN Xi 1,LI Xin 2,HAO Yaoguang 2,ZHAO Yiwen 2,ZHOU Jinghong 2,SHI Haishui 3 * #
1.Department of Functional region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011
2.Seven-Year Program Students of 2013 Grade, College of Basic Medicine, Hebei Medical University, Shijiazhuang,050017
3.Department of Bichemistry and Molecular Biology, College of Basic Medicine, Hebei Medical University, Shijiazhaung, 050017
*Correspondence author
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Funding: This work was supported in part by the National Natural Science Foundation of China （No.81201038, 31371140), the Special Foundation for Excellent Youth Investigator from Hebei Province of China）
Opened online: 3 December 2014
Accepted by: none
Citation: YIN Xi,LI Xin,HAO Yaoguang.Xylocarpin H, a component of Xylocarpus granatum, produces antidepressant-like activities in mice[OL]. [ 3 December 2014] http://en.paper.edu.cn/en_releasepaper/content/4620567
 
 
Major depression is a common psychiatric disorder worldwide that imposes a substantial health burden on society. Currently available antidepressants do not meet the clinical needs. Here, we report that Xylocarpin H, an active component of Xylocarpus granatum, has antidepressant-like effects in mouse models of depression. In mouse forced swimming- and tail suspension tests, two validated models of depression, oral administration of Xylocarpin H resulted in a dose-dependent decreased immobility duration within the dose range of 15-50 mg/kg. In addition, Xylocarpin H dose-dependently increased the time in the central zone at doses of 5-50 mg/kg in the locomotion activity test. The antidepressant-like activities of Xylocarpin H were associated with its inhibitory effects on hypothalamic-pituitary-adrenal (HPA) axis' hyperactivity in response to acute stress. Interestingly, these effective doses of Xylocarpin H did not affect locomotor- and HPA axis activities in the absence of stress. In summary, the present study, for the first time, demonstrated that Xylocarpin H exerts antidepressant-like effects in mouse behavioral models of depression, likely by inhibiting HPA axis systems. These data provide a strong basis for developing Xylocarpin H as a novel antidepressant agent for the treatment of major depression disorders.
Keywords:Xylocarpin H;antidepressant; tail suspension test; forced swimming test; hypothalamic-pituitary-adrenal axis
 
 
 

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