Evaluation of Scutellaria barbata D.Don ethanol extract and its components on antitumor effects of low dose 5-fluorouracil against hepatocellular carcinoma cells

XU Huanli; DU Guanhua

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Evaluation of Scutellaria barbata D.Don ethanol extract and its components on antitumor effects of low dose 5-fluorouracil against hepatocellular carcinoma cells

XU Huanli 1,DU Guanhua 2 *

1.Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

2.National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College

*Correspondence author

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Funding: This work was supported by the Natural Science Foundation of China （No.no. 81302906), Beijing Natural Science Foundation）

Opened online: 6 January 2015

Accepted by: none

Citation: XU Huanli,DU Guanhua.Evaluation of Scutellaria barbata D.Don ethanol extract and its components on antitumor effects of low dose 5-fluorouracil against hepatocellular carcinoma cells[OL]. [ 6 January 2015] http://en.paper.edu.cn/en_releasepaper/content/4625638

Background: Some compounds derived from Chinese medicine have demonstrated prospective roles in sensitization to chemotherapy. Aim: This study aimed to investigate Scutellaria barbata D.Don ethanol extract (SBEE) and its components on antitumor effects of low dose 5-fluorouracil against hepatocellular carcinoma cells. Methods: The antitumor effects of SBEE and its components, and their combinations with 5-FU were detected by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium/phenazine methosulfate assay, and the effects of drug combinations were evaluated using Jin's formula. Results:SBEE and luteolin could inhibit tumor growth in time and dose dependent manners. Drug combination study showed that SBEE and luteolin could synergize the antitumor effects of 5-fluorouracil at different dose ratios against HepG2 and Bel-7402 cells.Conclusion: SBEE and luteolin showed synergistic antitumor effects when combined with low dose 5-FU, and the mechanism of the synergistic effect remains to be to be studied.

Keywords:5-Fluorouracil; luteolin;apoptosis

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