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| 13 different Pearson mutual-positive-correlation EPHA4-activation molecular network was constructed from 53 overlapping of 166 GRNInfer and 70 Pearson under EPHA4 CC ≥0.25 in high human hepatocellular carcinoma (HCC) compared with low no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection). Our identified EPHA4 outside-inside-out interactive molecular network showed ALK (anaplastic lymphoma receptor tyrosine kinase), C9orf127 (chromosome 9 open reading frame 127), ARHGDIG (Rho GDP dissociation inhibitor (GDI) gamma) in high HCC. EPHA4 outside-inside-out interactive terms network includes integral to plasma membrane, membrane, transmembrane receptor protein tyrosine kinase signaling pathway, nucleus, cytoplasm, mitochondrion, endoplasmic reticulum, plasma membrane, cell surface, integral to membrane, membrane fraction, cytoplasmic membrane-bound vesicle; neurogenesis, axon guidance; nervous system development, brain development, cell adhesion, cell-matrix adhesion, regulation of progression through mitotic cell cycle, regulation of growth, negative regulation of cell adhesion; nucleotide-binding, transmembrane receptor protein tyrosine kinase activity, receptor signaling protein tyrosine kinase activity, receptor activity, protein-binding, ATP-binding, transferase activity, protein-tyrosine kinase activity, ephrin receptor activity, Rho GDP-dissociation inhibitor activity, GTPase activator activity based on integrative GO, KEGG, GenMAPP, BioCarta and disease databases in high HCC. Therefore, we propose high EPHA4 outside-inside-out interactive neuro-induced regulation of growth through ALK-C9orf127-ARHGDIG in HCC.????? |
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| Keywords:Biomedical Engineering; EPHA4 outside-inside-out interactive network; regulation of growth; neuro; ALK-C9orf127-ARHGDIG????? |
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