Effect of ADH1B Arg48His polymorphism on DNA damage induced by alcohol in esophageal squamous cell lines

Liang Weijun; Wei Zhang; Tian Dongping; Liu Xi; Xu Zexin; Huang Bo; Su Min

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Effect of ADH1B Arg48His polymorphism on DNA damage induced by alcohol in esophageal squamous cell lines

Liang Weijun,Wei Zhang,Tian Dongping,Liu Xi,Xu Zexin,Huang Bo #,Su Min *

Department of Pathology, Shantou University Medical College,Shantou 515031, Guangdong Province, China

*Correspondence author

#Submitted by

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Funding: 2015 Guangdong Specialized Funds for Cultivating College Students' Science and Technology Creativity （No.pdjh2015b0199), National Natural Science Foundation of China）, Specialized Research Fund for the Doctoral Program of Higher Education of China （No.New Teachers, No.20114402120006）, grants of National Natural Science Foundation of China （No.No. 81101548 and 31171226)）

Opened online:23 November 2015

Accepted by: none

Citation: Liang Weijun,Wei Zhang,Tian Dongping.Effect of ADH1B Arg48His polymorphism on DNA damage induced by alcohol in esophageal squamous cell lines[OL]. [23 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4661634

Previous studies reported that ADH1B Arg48His locus was susceptible to esophageal cancer, especially interacting with alcohol drinking, but the mechanism behind the association is not clear. The current study was to explore the effect of ADH1B Arg48His genotypes on alcohol induced DNA damage in esophageal squamous immortalized cell lines. NE2 and NE3 cell lines were performed sanger sequencing to genotype ADH1B Arg48His locus. After treatment with different concentrations of alcohol, DNA double strand breaks (γ-H2AX immunostaining) were detected by immunocytochemistry. We found that higher concentration of alcohol made more serious of DNA damage. In addition, the degree of DNA double strand breaks of NE3 with homozygote His/His genotype were significant serious than that of NE2 with heterozygote Arg/His genotype. These findings provide an important contribution to understanding the role of ADH1B polymorphisms in esophageal susceptibility and carcinogenesis.?????

Keywords:ADH1B, DNA damage, Esophageal squamous cell line

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