The Influence of Autophagy in Advanced Atherosclerosis

Zhu Yuning; Fan  Wenjing; Zhang Chi; Guo Fang; Li Wei; Wang Yufei; Jiang Zhisheng; Qu Shunlin

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The Influence of Autophagy in Advanced Atherosclerosis

Zhu Yuning 1 #,Fan Wenjing 2,Zhang Chi 2,Guo Fang 2,Li Wei 2,Wang Yufei 2,Jiang Zhisheng 2,Qu Shunlin 2 *

1.Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South ChinaUniversity of South China, Hengyang City, Hunan Province, PRC,421001

2.Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City, Hunan Province, PRC,421001

*Correspondence author

#Submitted by

Subject:

Funding: the Science and Technology Project of Hunan Province （No.2014FJ3014), the key Scientific Research Fund of Hunan Provincial Education Department）

Opened online: 9 December 2015

Accepted by: none

Citation: Zhu Yuning,Fan Wenjing,Zhang Chi.The Influence of Autophagy in Advanced Atherosclerosis[OL]. [ 9 December 2015] http://en.paper.edu.cn/en_releasepaper/content/4665970

Atherosclerosis (AS) is still the leading cause for cardiovascular disease global morbidity and mortality, such as it is a key cause of cardiopathy, myocardial infarction and peripheral vascular diseases. It does great harm to human health. Macrophages play a crucial role in atherosclerotic plaque stabilization and rupture. In this case, the selectivity of macrophage removal may be beneficial to the stability of the plaques. Autophagy is a catabolic recycling pathway that is triggered by various intracellular or extracellular stimuli and then during autophagy, diverse cytosolic constituents are enveloped by double-membrane vesicles, autophagosomes, which later fuse with lysosomes or the vacuole to degrade their cargo. Because autophagy has the function of maintaining cell homeostasis and promoting cell survival，and therefore imbalance in autophagy is related closely to a diverse range of pathologies including cardiovascular diseases, the leading cause of death in the world.

Keywords:Autophagy; Atherosclerosis; Molecular mechanism; Vacular; Treatment;

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