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Caldesmon is a key factor in contraction and stiffness of vascular smooth muscle cells
JIANG Qifeng * #
Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing 400016
*Correspondence author
#Submitted by
Subject:
Funding: Research Fund for the Doctoral Program of Higher Education （No.No. 20125503120018）
Opened online:19 May 2016
Accepted by: none
Citation: JIANG Qifeng.Caldesmon is a key factor in contraction and stiffness of vascular smooth muscle cells[OL]. [19 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4687312
 
 
In this paper, the potential role of CaD in mediating mechanical properties of VSMCs was probed and the regulatory effect of CaD on cell motilities was also discussed. First, structural effect of CaD on cytoskeleton integrity was analyzed with CaD knock-down; Second, Fourier transform traction cytometry was used to measure cell traction force dynamics; Third, the Optical Magnetic Twisting Cytometry was employed to determine cell stiffness dynamics. We found that CaD is an integral component to maintain cytoskeleton integrity of VSMCs. CaD not only sustains the basic value of contraction and stiffness of VSMCs in stationary condition, but also restores these mechanical parameters after cytoskeleton disruption.
Keywords:Caldesmon; VSMCs; Cytoskeleton
 
 
 

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