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Update on Alzheimer's neurodegeneration induced by amyloid precursor protein
ZHAO Dan,ZHAO Jie,LI Shao *
Department of Physiology, Dalian Medical University, Dalian 116044, China
*Correspondence author
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Funding: Research Fund for the Doctoral Program of Higher Education of China （No.20122105110010)）
Opened online: 3 June 2016
Accepted by: none
Citation: ZHAO Dan,ZHAO Jie,LI Shao.Update on Alzheimer's neurodegeneration induced by amyloid precursor protein[OL]. [ 3 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4693086
 
 
The loss of synapses between neurons as well as progressive neuronal degeneration and apoptosis is the basis of pathological Alzheimer's disease (AD), which directly induces progressive memorial and cognitive impairment of AD patients. Beta amyloid precursor protein (β-APP，APP) is commonly associated with senile plaques formation which is best known for the pathogenesis of AD. More and more studies have shown that the structure and the hydrolysic way of APP play very important roles in neuronal degeneration and apoptosis of AD by many ways. In this paper, we will overview the update progress for the pathophysiological mechanism of neuronal degeneration and apoptosis induced by APP, from the perspective of APP structure and its hydrolysis.
Keywords:Alzheimer's disease; amyloid precursor protein; neuronal degeneration
 
 
 

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