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Over-expression of LAPTM4B-35 and VEGF is related to poor prognosis in local advanced cervical carcinoma
Fanling Meng 1 #,Pan Shang 2,Hongtao Song 3,Ge Lou 1 *
1.Department of Gynecology, the Affliated Tomor Hospital of Harbin University, Harbin, China.
2.Department of Gynecology, the Taizhou People, Taizhou, China.
3.Department of Pathology, the Affliated Tomor Hospital of Harbin University, Harbin, China.
*Correspondence author
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Funding: Grant support: This work was supported by grants of the Specialized Research Fund for the Doctoral Program of Higher Education （No.20122307120027), the Postdoctoral Foundation of Heilongjiang Province of China）
Opened online:12 June 2016
Accepted by: none
Citation: Fanling Meng,Pan Shang,Hongtao Song.Over-expression of LAPTM4B-35 and VEGF is related to poor prognosis in local advanced cervical carcinoma[OL]. [12 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4693517
 
 
Objectives: Patients with locally advanced cervical cancer (LACC) are difficult to treat. The purpose of this study is to investigate lysosome-associated protein transmembrane 4?-35 (LAPTM4B-35) and vascular endothelial growth factor (VEGF) expression in LACC and evaluate their clinicopathological and prognostic significance. Methods: The expression of LAPTM4B-35 and VEGF proteins was analyzed by immunohistochemistry in 119 LACC and 40 normal cervical specimens. Results: LAPTM4B-35 and VEGF were expressed in 73.9% and 75.6% of cervical cancer, respectively, which are higher than the normal cervical tissues. LAPTM4B-35 expression was positively correlated with the expression of VEGF. The expression of LAPTM4B-35 and VEGF was significantly correlated with FIGO stage, Histological grade and lymph node metastasis (P<0.05). Kaplan-Meier analysis showed that LACC patients with high expression of LAPTM4B-35 and VEGF exhibited poor overall survival (OS) and disease-free survival (DFS) (P<0.05). Conclusions: We demonstrate that LAPTM4B-35 correlates with VEGF and is a poor prognostic factor in local advanced cervical cancer.
Keywords:Lysosomal protein transmembrane 4 beta; Vascular endothelial growth factor; Immunohistochemistry; Local advanced cervical cancer; Prognosis
 
 
 

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