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Fucans isolated from Isostichopus badionotus induces apoptotic-like cell death in human gastric cancer cell HGC-27 under hypoxia
GE Yuan 1,LI Hui 2,WANG Jingfeng 2 *
1.College of Marine Life Science, Ocean University of China
2.College of Food Science and Engineering, Ocean University of China
*Correspondence author
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Funding: none
Opened online:22 June 2016
Accepted by: none
Citation: GE Yuan,LI Hui,WANG Jingfeng.Fucans isolated from Isostichopus badionotus induces apoptotic-like cell death in human gastric cancer cell HGC-27 under hypoxia[OL]. [22 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4695036
 
 
In this paper, the anti-cancer function of fucans isolated from marine cucumber Isostichopus badionotus was investigated and analysed. We proved the anti-cancer activity of fucan-Ib in human gastric cancer cells HGC-27 under hypoxia through the induction of apoptosis. Furthermore, we also revealed the underlying molecular mechanism, a caspase-3 dependent pathway, of fucan-Ib induced apoptosis in cancer cells under hypoxia. These results provide basic knowledges and evidence on the medicinal values of fucan-Ib.
Keywords:Biochemistry;fucans;Isostichopus badionotus; apoptosis
 
 
 

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