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NMDA receptor blockade suppresses pentylenetetrazole-induced acute seizure and kindling
Yong Qianye 1,Li Shujun 2,Wang Huize 3,Kong Lingwen 2,Li Siqi 3,Zhu Xinjian 4 * #
1.Medical imaging, Medical School of Southeast University, Nanjing 210009
2.Medical laboratory, Medical School of Southeast University, Nanjing 210009
3.Clinical Medicine, Medical School of Southeast University, Nanjing 210009
4.Department of Pharmacology, Medical School of Southeast University, Nanjing 210009
*Correspondence author
#Submitted by
Subject:
Funding: Natural ScienceFoundation of Jiangsu Province (No.No. BK20141335 to Xinjian Zhu), Specialized Research Fund for the Doctoral Program of Higher Education Foundation (No.No. 20130092120043 to Xinjian Zhu)
Opened online:18 October 2016
Accepted by: none
Citation: Yong Qianye,Li Shujun,Wang Huize.NMDA receptor blockade suppresses pentylenetetrazole-induced acute seizure and kindling[OL]. [18 October 2016] http://en.paper.edu.cn/en_releasepaper/content/4705952
 
 
N-methyl-D-aspartate (NMDA) receptor plays an important role in the pathophysiology of several neurological diseases, including epilepsy. The present study, therefore, using the non-competitive NMDA receptor antagonist, MK-801 to investigate the role of NMDA receptor in pentylenetetrazole (PTZ)-induced kindling and the possible cellular and molecular mechanisms involved. Our results showed that acute seizure was induced in male C57BL/6 mice with a single dose of PTZ (60mg/kg), while kindling was induced with a subconvulsive dose of PTZ (35mg/kg) for at least 9 injections. Blocking NMDA receptor by non-competitive antagonist MK-801, however, significantly suppressed PTZ-induced acute seizure and the development of kindling. These results indicate that PTZ-induced acute seizure and kindling are dependent on NMDA receptor activation.
Keywords:NMDA receptor; seizure; kindling; hippocampus
 
 
 

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