Home > Papers

 
 
Fetal exposure to angiotensin II type 1 autoantibody induces hepatic insulin resistance in the adolescent offspring of rats
WEI Mingming 1,ZHANG Suli 1,YANG Xiaoli 2,WANG Li 3,ZHAO Chengrui 4,LEI Jinghui 1,WANG Pengli 1,LIU Huirong 1 * #
1.Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, P. R. China
2.Assisted Reproduction Center, Taiyuan City Central Hospital, Taiyuan, Shanxi, 030009, P. R. China
3.Department of Pathology, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China
4.Department of Physiology, Basic Medical Department, Fenyang College of Shanxi Medical University, Fenyang, Shanxi, 032200, P. R. China
*Correspondence author
#Submitted by
Subject:
Funding: National natural science foundation of China (No.NO.81300694), The specialized research fund for the doctoral program of higher education (No.NO. 20131107120021), National natural science foundation of China (No.NO.81471478), The Beijing natural science foundation of China (No.NO.7152017)
Opened online:16 February 2017
Accepted by: none
Citation: WEI Mingming,ZHANG Suli,YANG Xiaoli.Fetal exposure to angiotensin II type 1 autoantibody induces hepatic insulin resistance in the adolescent offspring of rats[OL]. [16 February 2017] http://en.paper.edu.cn/en_releasepaper/content/4718781
 
 
Fetal origin of adult disease has gained lots of attention in relation to the occurrence of insulin resistance. Studys found offspring of pregnant rats tested positive for angiotensin II type 1 receptor autoantibody (AT1-AA) exhibited both liver damage and systemic insulin resistance during adulthood. But the mechanism and time-course associated with symptom remain unclear. Normal pregnant rats were administered with preeclampsia serum-derived AT1-AA in the second trimester to establish AT1-AA positive pregnant rat models. Compared to saline group, fasting serum glucose and insulin levels, insulin resistance index values were higher, and impaired glucose tolerance, abnormal insulin tolerance, islet compensatory hypertrophy were observed in adolescent and middle-aged offspring of AT1-AA group. Triglyceride and systolic blood pressure levels were elevated in adolescence. Hepatic glycogen synthetase reduced in the third trimester, adolescence and middle age. Expression of insulin receptor subunit, insulin receptor substrate 1/2, and their phosphoprotein decreased in hepatic insulin signaling pathway of adolescent and middle-aged offspring of AT1-AA group. We found the offspring of AT1-AA positive pregnant rats exist insulin resistance in adolescence. Meanwhile, hepatic insulin receptor and downstream receptor pathway disorder may be an important mechanism of insulin resistance in AT1-AA positive pregnant rat offspring.
Keywords:angiotensin II Type 1 Autoantibodies; offspring; hepatic insulin resistance; metabolic disorders
 
 
 

For this paper

  • PDF (0B)
  • ● Revision 0   
  • ● Print this paper
  • ● Recommend this paper to a friend
  • ● Add to my favorite list

    Saved Papers

    Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags

Add yours

Related Papers

Statistics

PDF Downloaded 78
Bookmarked 0
Recommend 0
Comments Array
Submit your papers