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Seroprevalence of Hepatitis E among Pregnant Women in Zhenjiang, China
Rui Zhilian 1,Xiaochun Wang 2,Yang Yan 3,Peng Ying 1,Zhao Xiaoying 2,Wen Zhang 2,Fu Xingli 2,Zhou Chenglin 4,Yang Shixing 2,Shen Quan 2 *
1.Liyang People's Hospital, Liyang 213314
2.School of Medicine, Jiangsu University, Zhenjiang 212013
3.The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang 212001
4.Taizhou People's Hospital, Taizhou 225300
*Correspondence author
#Submitted by
Subject:
Funding: The Ph.D Programs Foundation of the Ministry of Education of China (No.No. 20133227120010), The authors would like to thank for the financial supports from National Natural Science Fund of China (No.Grant No. 31402211), Jiangsu Planned Projects for Postdoctoral Research Funds, (No.No. 1301142C)), The Natural Science Foundation of Jiangsu Province (No.No. BK20140578), China Postdoctoral Science Foundation)
Opened online: 7 April 2017
Accepted by: none
Citation: Rui Zhilian,Xiaochun Wang,Yang Yan.Seroprevalence of Hepatitis E among Pregnant Women in Zhenjiang, China[OL]. [ 7 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4723385
 
 
Backgroud: HEV is the most common cause of acute viral hepatitis in the worldwide. Most of HEV infections are mild or subclinical, nevertheless, hepatitis E (HE) is characteristically associated with a high occurrence of symptomatic presentations of clinical syndrome in pregnant women. Objectives: So far, only few cases of HE during pregnancy have been reported, and the data of seroprevalence among pregnant women was extremely limited. The aim of this study is to assess the HEV prevalence in the pregnant women in Zhengjiang, China. Materials and Methods: A total of 225 serum samples taken from pregnant women were subjected to detection of anti-HEV. IgM positive samples were tested for HEV RNA by using reverse transcription-nested PCR method. Positive PCR products were sequenced and phylogenetically analyzed. Results: The prevalence of anti-HEV IgG and IgM in pregnant women were 21.8% (49/225) and 3.6% (8/225), respectively. Four of the eight IgM positive samples were positive to HEV RNA. Phylogenetic analyses indicated that the 4 HEV strains had distinct nucleotide sequence and were divided into two different subgenotypes in genotype 4. Conclusions: The prevalences in current study for IgG and IgM were higher than those in the other regions of China. Additional, all of the four strains belonging to genotype 4 suggested that the genotype 4 was the predominant genotype in this area.
Keywords:Hepatitis E virus, pregnant women, seroprevalence, genotype
 
 
 

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