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Comprehensive long non-coding RNA expression profiling reveals their potential roles in systemic lupus erythematosus
Li Lianju,Ye Dongqing * #
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032
*Correspondence author
#Submitted by
Subject:
Funding: National Natural Science Foundation of China (No.81473058, 81271759, 81673258)
Opened online:27 April 2017
Accepted by: none
Citation: Li Lianju,Ye Dongqing.Comprehensive long non-coding RNA expression profiling reveals their potential roles in systemic lupus erythematosus[OL]. [27 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4725270
 
 
long non-coding RNAs can regulate gene transcription, modulate protein function, and act as competing endogenous RNA. Yet, their roles in systemic lupus erythematosus remain to be elucidated. We determined the expression profiles of lncRNAs in T cells of SLE patients and healthy controls using microarrays. Up to 1935 lncRNAs and 1977 mRNAs were differentially expressed. QRT-PCR showed downregulated uc001ykl.1 (P=0.004) and ENST00000448942 (P=0.009) in SLE patients. Expression of uc001ykl.1 correlated with erythrocyte sedimentation rate and C-reactive protein, whereas ENST00000448942 level correlated with ESR and anti-Sm antibodies. Short time-series expression miner analysis revealed some lncRNAs whose expressions might correlate with disease activity of SLE patients. Coding-non-coding gene coexpression analyses showed differential lncRNAs might operate via modulating expressions of their correlated, relevant mRNAs in SLE. Differential lncRNAs might also function through their ceRNAs. Our study established that the aberrant expression profiles of lncRNAs may play a role in SLE and thus warrant further investigation.
Keywords:Epidemiology; long non-coding RNA; systemic lupus erythematosus; Non-coding RNA; microRNA; ceRNA
 
 
 

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