Aberrant levels of circulating endothelial progenitor cells in type 2 diabetes mellitus patients with or without proliferative diabetic retinopathy

Zhang Jingkai; Chen Qingzhong; Zhang Wei; Mao Chunjie; Zhang Zhuhong; Huang Bo; Yan Hua

Chinese︱Feedback︱Save this page

• Elaborating Academic Views 　　　　 • Exchanging Innovative Ideas
• Protecting Intellectual Properties 　　• Fast Sharing Science Papers

Sponsored by the Center for Science and Technology Development of the Ministry of Education
Supervised by Ministry of Education of the People's Republic of China

Home > Papers

Aberrant levels of circulating endothelial progenitor cells in type 2 diabetes mellitus patients with or without proliferative diabetic retinopathy

Zhang Jingkai 1,Chen Qingzhong 1,Zhang Wei 2,Mao Chunjie 1,Zhang Zhuhong 1,Huang Bo 3,Yan Hua 1 *

1.Tianjin Medical University General Hospital,Department of Ophthalmology,Tianjin China 300052

2.Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Tianjin China 300020

3.Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS 39216 USA

*Correspondence author

#Submitted by

Subject:

Funding: Research Fund for the Doctoral Program of Higher Education of China （No.20131202110007）

Opened online:27 April 2017

Accepted by: none

Citation: Zhang Jingkai,Chen Qingzhong,Zhang Wei.Aberrant levels of circulating endothelial progenitor cells in type 2 diabetes mellitus patients with or without proliferative diabetic retinopathy[OL]. [27 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4728085

Purpose: To investigate the number and function of circulating endothelial progenitor cells (EPC) in patients with type 2 diabetes mellitus (T2DM) with or without proliferative diabetic retinopathy (PDR). Methods: Circulating EPCs were isolated from 30 T2DM patients with PDR (60 eyes), 30 T2DM patients without PDR (60 eyes), as well as age matched control subjects (n=20). EPCs isolated from peripheral blood were quantified using flow cytometric analysis to count the number of CD34+, CD133+and VEGF R2+ cells. Following isolation, the EPCs were cultured in vitro to evaluate proliferation, adhesion and migration. Results: The number of circulating EPCs was significantly decreased in T2DM patients with and without PDR when compared with the healthy control individuals. In addition, the number of EPCs in the cultured samples from T2DM patients with and without PDR was lower compared with the control individuals. Furthermore, impaired proliferation, adhesion and migration were observed in the cultured EPCs from T2DM patients with and without PDR. Notably, increased numbers and aggravated dysfunction of EPCs were detected in T2DM patients with PDR compared with T2DM patients without PDR. In addition, a positive correlation was identified between the EPC number and PDR duration in T2DM patients with PDR.Conclusion: Reduced number and impaired function of circulating EPCs were observed in T2DM patients with or without PDR. In conclusion, EPC levels and aggravated EPC dysfunction in patients with PDR compared with patients without PDR may contribute to the pathogenesis of PDR in T2DM patients. EPC levels may be used as indicators in order to monitor PDR.

Keywords:endothelial progenitor cells; type 2 diabetes mellitus; diabetic retinopathy

For this paper

● PDF (0B)
● Revision 0 　　
● Print this paper
● Recommend this paper to a friend
● Add to my favorite list

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags

Add yours

Related Papers

Other similar papers

Statistics

PDF Downloaded	61
Bookmarked	0
Recommend	0
Comments	Array

Submit your papers

Alert Name:
Alerting to:
Authentication email will be sent to your email address in 24 hours
Frequency:
Email Message Format:	Plain text Graphical(HTML)

Complete the form below and we will recommend the selected titles to your friends on your behalf. * Indicates a required field.
Your name*:
Your email address*:
Recipient's name*:
Recipient's email address*:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find the page(s) useful.

Your name:
Your email address:
Recipient's name:
Recipient's email address:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find this page useful.

Disclaimer: This message was sent to your friend using the "Send it to a friend" facility on the Sciencepaper Online’ WWW site, http://www.paper.edu.cn/en. The Sciencepaper Online is not responsible for the content of this email, and anything said in this email does not necessarily reflect the Sciencepaper Online's views.

	Check out RSS, or use RSS reader to subscribe this item

Saved Papers