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Effects of Alprostadil on reducing plasmas D-dimer level and incidence of venous thromboembolism after radical prostatectomy: a randomized prospective cohort study
YAN Yangye 1,XIE Tiancheng 2,XU Yunfei 2,LUO Ming 1 * #
1.Department of Urology, Shanghai Tenth People\'s Hospital, Tongji University, Shanghai, 200072, China
2.Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China
*Correspondence author
#Submitted by
Subject:
Funding: Specialized Research Fund for the Doctoral Program of Higher Education（No.20130072120049）
Opened online: 4 May 2017
Accepted by: none
Citation: YAN Yangye,XIE Tiancheng,XU Yunfei.Effects of Alprostadil on reducing plasmas D-dimer level and incidence of venous thromboembolism after radical prostatectomy: a randomized prospective cohort study[OL]. [ 4 May 2017] http://en.paper.edu.cn/en_releasepaper/content/4729881
 
 
Objectives: To investigate the effects of alprostadil on reducing plasma D-dimer level and incidence of venous thromboembolism after radical prostatectomy. Methods: This randomized prospective cohort study recruited 130 patients diagnosed with prostate cancer and received radical prostatectomy from September 2014 to January 2016 in Shanghai tenth People's Hospital. Patients were randomly assigned to an alprostadil group (n=65) and a control group (n=65). Alprostadil group received 10ug/d of alprostadil diluted in 10ml of normal saline through an intravenous injection over 5 min starting on operation day and continuing for 1 week after surgery. Plasma D-dimer levels were measured preoperatively, on the operation day and on 1st, 3rd, 5th, 7th days after surgery. All patients underwent Doppler ultrasonography evaluation of bilateral lower limbs on 7th day after surgery. The outcome of the study was analyzed using SPSS 20.0 software and via χ2 test and repeated measures analysis of variance. Results: Comparing to that in control group, the plasma D-dimer level was significantly decreased on the 7th day (p=0.000) after operation, and the incidence of venous thromboembolism was significant lower (3.1% vs. 15.4%, p=0.030) in alprostadil group. Conclusion: Systemic treatment of alprostadil for at least 1 week after radical prostatectomy contributes to the decreasing of plasma D-dimer level and incidence of venous thromboembolism.)
Keywords:alprostadil; D-dimer; prostaglandin E1; radical prostatectomy; venous thromboembolism
 
 
 

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