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Pharmacokinetics of Terminalia Phenolics in Rats after Oral Administration of a Mongolian Compound Medicine Alatan-5
Wu Dandan,Azzaya Jukov,Ma Chaomei * #
School of Life Sciences, Inner Mongolia University, Huhhot 010021
*Correspondence author
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Funding: This work was supported by Specialized Research Fund for the Doctoral Program of Higher Education (No.20131501110008))
Opened online:11 May 2017
Accepted by: none
Citation: Wu Dandan,Azzaya Jukov,Ma Chaomei.Pharmacokinetics of Terminalia Phenolics in Rats after Oral Administration of a Mongolian Compound Medicine Alatan-5[OL]. [11 May 2017] http://en.paper.edu.cn/en_releasepaper/content/4732391
 
 
This paper reports the pharmacokinetic properties of Terminalia phenolics after administration of Alatan-5 which is a compound Mongolian medicine containing the fruit of T. chebula in combination with four other medicines. Gallic acid, ellagic acid, casuarinin, and chebulic acid were detected and quantified in the rat plasma. Gallic acid showed the largest AUC value among these four constituents when Alatan-5 was administrated, and its AUC value was larger than when T. chebula fruit was used alone. While the AUC values of the other constituents were smaller when Alatan-5 was used than when T. chebula fruit was administrated alone. These data indicated that gallic acid and other Terminalia phenolics could play important roles in the pharmacologic effects of Alatan-5 and that other medicines in this compound Mongolian medicine could greatly alter the pharmacokinetic behaviors of Terminalia phenolics.
Keywords:Traditional Mongolian medicines; Alatan-5; Terminalia phenolics; Pharmacokinetics
 
 
 

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