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The role of protein phosphorylation in mitochondria
Xiaolu Zhao * #
College of Life Sciences, Wuhan University
*Correspondence author
#Submitted by
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Funding: 高等学校博士学科点专项科研基金 （No.20130141120086）
Opened online:18 May 2017
Accepted by: none
Citation: Xiaolu Zhao.The role of protein phosphorylation in mitochondria[OL]. [18 May 2017] http://en.paper.edu.cn/en_releasepaper/content/4732969
 
 
Mitochondria play a central role in energy metabolism and cellular survival, and consequently mitochondrial dysfunction is associated with a number of human pathologies, such as type 2 diabetes. There is an increasing understanding/interest of the use of reversible protein phosphorylation as a central mechanism in regulating various mitochondrial processes. E.g. in skeletal muscle, aberrant phosphorylation of mitochondrial proteins has been hypothesized to play a role for the link between mitochondrial dysfunction and insulin resistance in humans with obesity and type 2 diabetes. This review summarizes previous studies on the role of protein phosphorylation in mitochondrial functions, mass spectrometry-based phosphoproteomics strategies and phosphoproteomic studies of mitchondria.
Keywords:mitochondria; protein phosphorylation; phosphoproteomics;mass spectrometry
 
 
 

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