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Dental Pulp Stem Cells in Tooth Regeneration: Characterizations and Applications
Su Cheng 1,Zhu Guanyin 2,Zheng Yi 2,Gao Bo 2 *
1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodonics West China Hospital of Stomatology, Sichuan University, Chengdu, China;State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodonics West China Hospital of Stomatology, Sichuan University, Chengdu, China;State Key Laboratory of Oral Diseases & National
2.
*Correspondence author
#Submitted by
Subject:
Funding: National Natural Science Foundation of China (No.No. 81300875), Specialized Research Fund for the Doctoral Program of Higher Education (No.No. 20130181120083)
Opened online:17 November 2017
Accepted by: none
Citation: Su Cheng,Zhu Guanyin,Zheng Yi.Dental Pulp Stem Cells in Tooth Regeneration: Characterizations and Applications[OL]. [17 November 2017] http://en.paper.edu.cn/en_releasepaper/content/4741871
 
 
In order to make up the deficiency of traditional medical treatment method, regenerative medicine as a new research field has received extensive attention in the recent years. Dental pulp stem cells(DPSCs), originating from the neural crest, become a promising source for tooth regeneration applications for their unique advantages, such as easily isolated and minimally invasive. As a kind of mesenchymal stem cells, DPSCs have the ability to differentiate in several cell phenotypes including odontogenic differentiation, vascularization and neural differentiation. To be applied in tissue engineering, DPSCs are usually combined with various scaffolds and growth factors. Based on the characterizations of DPSCs, they are considered to be a great candidate for application used in regenerative endodontic procedures and whole tooth regeneration. In this review, we have carefully described the important aspects of DPSCs and discussed the practical applications in the present studies. this paper.
Keywords:DPSCs; tooth regeneration; tissue engineering; regenerative medicine
 
 
 

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