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| High tyrosine hydroxylase (TH) upstream-inhibited cytoplasmic FMR1 interacting protein 2 (CYFIP2) molecular subnetwork was constructed, including feedback SMAD family member 1 (SMAD1_2); downstream Rho GTPase activating protein 12 (ARHGAP12), forkhead box N3 (FOXN3_2) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited CYFIP2 subnetwork was identified by DAVID, containing feedback SMAD1_2, downstream FOXN3_2, second-core CYFIP2, first-core TH as protein binding; feedback SMAD1_2, downstream FOXN3_2 as transcription factor activity sequence specific DNA binding; downstream ARHGAP12, second-core CYFIP2 as small GTPase mediated signal transduction; The common cellular component of feedback SMAD1_2, downstream FOXN3_2, second-core CYFIP2, first-core TH as nucleus; feedback SMAD1_2, downstream ARHGAP12, second-core CYFIP2, first-core TH as cytosol; feedback SMAD1_2, second-core CYFIP2, first-core TH as cytoplasm; second-core CYFIP2, first-core TH as neuron projection; The common tissue distributions as ADIPOCYTE_3rd, CD8+T cells_3rd, PLACENTA_3rd, salivarygland_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited cytoplasmic FMR1 interacting protein 2 (CYFIP2) subnetwork for learning in human left hemisphere|ADIPOCYTE|CD8+T cells|PLACENTA|salivarygland via cytoplasm to nucleus small GTPase mediated signal transduction. |
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| Keywords:TH upstream-inhibited CYFIP2 subnetwork for learning; human left hemisphere|ADIPOCYTE|CD8+T cells|PLACENTA|salivarygland; cytoplasm to nucleus; small GTPase mediated signal transduction |
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