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| Purpose Hematological changes related to osteoporosis in elder people are largely unknown. Our aim is to systemically evaluate associations between platelet parameters and osteoporosis in two large Chinese elder populations. Materials and Methods Subjects were selected from our ongoing cohort study: Osteoporosis Preventive Project (OPP), they were 982 from Shishan Community Health Center (Sample 1) and 3675 from Loujiang Community Health Center (Sample 2).The two hospitals used different models of instruments to detect platelet parameters, namely, Mindray BC-5800 automatic five-class blood cell analyzer and Mindray BC-2600 automatic three-class blood cell analyzer. Platelet parameters include platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT). BMD (g/cm2) was measured by dual-energy X-ray absorptiometry with Hologic densitometers (Hologic Inc., USA). We performed the Kruskal-Wallis rank test, Spearman correlation analysis and partial correlation analysis to detect the associations between the platelet parameters and BMD. Results Since most of basic characteristics of the two samples differed significantly (P＜0.001), we separately analyzed the two samples. Among three groups categorized by LS BMD, PLT, PDW, and PCT were significantly different among the three groups. These results were consistent and replicated in the two samples (P<0.05). Similarly, significant differences only for PLT (P=0.003) and PCT (P=0.004) were observed in the Sample 2 among three groups categorized by FN BMD. The PLT and PCT were negatively correlated with LS BMD and FN BMD (P<0.01) in both samples when unadjusted, but after adjustment with sex, age and BMI, only two correlations were still significant (PLT and FN BMD, PCT and FN BMD in the Sample 2). Contrary to PLT and PCT, PDW was positively associated with LS BMD and FN BMD when unadjusted in both samples (P<0.01). However, the significantly positive correlations were only observed in the Sample 2 after adjustment. Conclusion The results suggest that three parameters (PLT, PDW and PCT) have significant correlations with BMD, but MPV has no associations with BMD. |
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| Keywords:Platelet parameters; Osteoporosis; Bone mineral density |
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