Simultaneous determination of concentration and enantiomeric excess of amino acids with a coumarin-derived achiral probe

YANG Lamei; WEI Weili

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Simultaneous determination of concentration and enantiomeric excess of amino acids with a coumarin-derived achiral probe

YANG Lamei 1,WEI Weili 2 *

1.School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331.;School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331.

*Correspondence author

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Funding: National Natural Science Foundation of China （No.No. 21675016)）

Opened online:31 March 2021

Accepted by: none

Citation: YANG Lamei,WEI Weili.Simultaneous determination of concentration and enantiomeric excess of amino acids with a coumarin-derived achiral probe[OL]. [31 March 2021] http://en.paper.edu.cn/en_releasepaper/content/4754323

The chirality of amino acids plays important role in biological and medical sciences. The development of achiral small-molecule probes that can simultaneously determine the absolute configuration, enantiomeric excess, and total concentration of amino acids is significant. The current available achiral coumarin aldehyde probe that could form Schiff bases with free amino acids at room temperature to induce the CD signals and to change UV-vis signals. The red-shifted UV-vis signals were independent of the substrate\'s chirality and could be used to determine the total concentration. Conversely, the enantioselective CD signals could be used to determine the absolute configuration and enantiomeric excess. The usefulness and practicability of this sensing method were demonstrated by analyzing 6 non-racemic phenylalanine samples with different enantiomeric compositions and concentrations.

Keywords:Optical chiral sensing; Enantioselectivity; Coumarin aldehyde; Amino acids

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