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| Lung cancer is the leading cause of cancer deaths worldwide. Despite the extensive characterization of events, which contribute to tumor initiation and progression, more and more recent studies forces on the relationship between circadian rhythm, like shift work and jet lag, and lung tumorigenesis. It is clear that the circadian clock system in lung is not only controlled by SCN, but also isolated from the SCN in some ways. There exists a negative and positive transcription/translation-based feedback loops in lung. Therefore, that the disorder of circadian clock system can lead to the risks of lung cancer has been described in multiple ways, including genes, cells, metabolism, immune function and inflammation processes and so on. This review emphasizes the important role of the circadian clock system in lung cancer, integrates the multiple relationship between circadian clock system and lung tumorigenesis, and hence puts forward new prospects in the prevention and cure of lung cancer. |
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| Keywords:circadian clock, lung cancer, inflammation |
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