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| Osteosarcoma is the most common primary malignant bone tumor, which is prone to early metastasis and poor prognosis. The current treatment methods need to be improved. Circular RNA is a covalently blocked circular endogenous non-coding RNA, which plays an essential role in the occurrence, development, clinical diagnosis, and treatment of various diseases. Understanding its role in osteosarcoma is conducive to the early detection, diagnosis, and treatment of osteosarcoma. In this paper, we reviewed the mechanism of action of circular RNA in the occurrence and development of osteosarcoma and its clinical application in recent years. |
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| Keywords:Osteosarcoma1, Circular RNA2, Occurrence3, Development4, Diagnosis5, Treatment6, Exosome7 |
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