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Decidual TLR signal response associated with TNF-α regulate the uterine spiral artery transformation of CBA×DBA/2 mice
Zhang Jianhong 1,Sun Rui 1,Wei Haiming 2,Wu Dongmei 3,Tian Zhigang 1
1.Institute of Immunology, School of Life Sciences, University of Sciences and Technology of China
2.Institute of Immunology- School of Life Sciences, University of Sciences and Technology of China
3.nstitute of Immunology, School of Life Sciences, University of Sciences and Technology of China
*Correspondence author
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Funding: 教育部博士点基金（No.20030358044）
Opened online:14 November 2006
Accepted by: none
Citation: Zhang Jianhong,Sun Rui,Wei Haiming.Decidual TLR signal response associated with TNF-α regulate the uterine spiral artery transformation of CBA×DBA/2 mice[OL]. [14 November 2006] http://en.paper.edu.cn/en_releasepaper/content/9512
 
 
The objective of this study was to examine the expression of Toll-like receptor (TLR) 3 at maternal fetal interface and determine whether exposure to the TLR3 agonist would induce innate immune response and trigger pregnancy loss. To address this, abortion-prone male DBA/2J mated-CBA/J female mice were given polyinosinic-polycytidylic acid (poly I:C, 10 μg/g·body weight, i.p.) or PBS at gestation day (gd) 6.5. All implantation sites appeared viable at gd 7.5 when endometrium was dissected for immunohistological examination. It was noted that poly I:C treatment increased fetal losses to 40.2±1.7% at midgestation stage, compared with control animals (11.0±3.0%). It was also observed that the ratio of vessel area to lumen area significantly increased at gd 10.5 and gd 12.5 after poly I:C treatment, indicating that the spiral arterial (SA) modification was impaired. Meanwhile, twenty-four hours after poly I:C injection, the expression of TLR3 dramatically elevated within decidua basalis (DB), and content of the endometrial TNF-α increased 2.7 fold but IFN-γ remained unchanged in homogenized endometrium. These results suggested that enhanced TNF-α expression in endometrial stroma may play a critical role in inflammatory factor production and the impairment of uterine spiral artery remodeling in the pregnancy failure of CBA×DBA/2 mating
Keywords:TLR3; poly I:C; TNF-α; spiral artery; pregnancy loss
 
 
 

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