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Golgi apparatus localization of ZNT7 in the mouse cerebellum
Hui-Ling Gao 1 #,Xin Wang 1,Zhihong Chi 1,Liping Huang 2,Zhanyou Wang 1 *
1.Department of Histology and Embryology，China Medical University
2.USDA/ARS/Western Human Nutrition Research Center，Department of Nutrition and Rowe Program in Genetics，University of California at Davis
*Correspondence author
#Submitted by
Subject:
Funding: 国家自然科学基金,国家自然科学基金,中国博士后科学基金,教育部博士点基金,新世纪优秀人才支持计划（No.30670722,30770680,2005037008,20060159001,NCET-04-0288）
Opened online:30 December 2007
Accepted by: none
Citation: Hui-Ling Gao,Xin Wang,Zhihong Chi.Golgi apparatus localization of ZNT7 in the mouse cerebellum[OL]. [30 December 2007] http://en.paper.edu.cn/en_releasepaper/content/17595
 
 
The cerebellum contains a significant amount of zinc ions. However, little is known about zinc homeostasis in the cerebellum. We have recently reported that four members of the zinc transporter (ZNT) family, ZNT1, ZNT3, ZNT4, and ZNT6, are abundantly expressed in the mouse cerebellum. In the present study, we reported that ZNT7 was present throughout the cerebellar cortex. ZNT7 immunoreactivity was predominately present in the somas and primary dendrites of the Purkinje cells. ZNT7 was also present in the Bergmann glial cell bodies as well as their radial processes, which extended into the molecular cell layer. Confocal immunofluorescence results demonstrated that the expression of ZNT7 overlapped with that of TGN38 in the somas of the Purkinje cells and granule cells. Immuno-electron microscopic study showed that ZNT7 was localized to the membrane of the Golgi apparatus in the somas of the Purkinje cells, Bergmann glial cells, and granule cells. Western blot analysis demonstrated that a considerable amount of ZNT7 was expressed in the cerebellum compared to the hippocampus. In addition, zinc autometallographic staining revealed that chelatable zinc was predominately distributed in the Bergmann glial cell bodies and their radial processes. These findings suggest a significant role of ZNT7 in zinc homeostasis in the mouse cerebellum.
Keywords:zinc transporter; cerebellum; Purkinje cells; Bergmann cell; mouse
 
 
 

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