Improved Taboo Search Algorithm for Designing DNA Words

Kai Zhang; Jin Xu; Xiutang Geng; Jianhua Xiao; Linqiang Pan

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Improved Taboo Search Algorithm for Designing DNA Words

Kai Zhang,Jin Xu,Xiutang Geng,Jianhua Xiao,Linqiang Pan * #

Huazhong University of Science and Technology

*Correspondence author

#Submitted by

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Funding: 国家自然科学基金，the Program for New Century Excellent Talents in University（No.60373089, 6067410630570431, 60703047, and 60533010，NCET-05-0612，20060487014，200750731262）

Opened online:27 March 2008

Accepted by: none

Citation: Kai Zhang,Jin Xu,Xiutang Geng.Improved Taboo Search Algorithm for Designing DNA Words[OL]. [27 March 2008] http://en.paper.edu.cn/en_releasepaper/content/19759

The design of DNA sequences is one of the most practical and important research topics in DNA computing. We adopt taboo search algorithm and improved the method for the systematic design of equal-length DNA sequences, which could satisfy certain combinatorial and thermodynamic constraints. Using taboo search algorithm, our method can avoid trapping into local optimization and can find greatest DNA sequences sets which satisfy required constraints.

Keywords:NA Computing; Taboo Search Algorithm; DNA Sequences Design

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