MALDI-TOF-MS Analysis of Small Molecules Using Modified Mesoporous Material SBA-15 as Assisted Matrix

Xiuhua, Li; Xue, Wu; Donghao, Li

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MALDI-TOF-MS Analysis of Small Molecules Using Modified Mesoporous Material SBA-15 as Assisted Matrix

Xiuhua, Li,Xue, Wu,Donghao, Li *

Key Laboratory of Nature Resource and Functional Molecular of the Changbai Mountain, Ministry of Education

*Correspondence author

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Funding: none

Opened online: 6 April 2009

Accepted by: none

Citation: Xiuhua, Li,Xue, Wu,Donghao, Li.MALDI-TOF-MS Analysis of Small Molecules Using Modified Mesoporous Material SBA-15 as Assisted Matrix[OL]. [ 6 April 2009] http://en.paper.edu.cn/en_releasepaper/content/31086

Mesoporous silica, SBA-15 has been successfully functionalized with quinoline moiety and applied to MALDI-TOF-MS analysis of small molecules as a matrix. The modified SBA-15 material (SBA-15-8-(3-(triethoxysilyl)propoxy)quinoline, SBA-15-8QSi) were obtained by using calcined SBA-15 and 8-hydroxyl quinoline. The structure of the functionalized mesoporous was systemically characterized with TEM technique, N2 adsorption-desorption isotherms technique and FT-IR spectra. Compared with DHB and SBA-15, it is demonstrated several advantages in the analysis of low molecules with MALDI-TOF-MS, such as less background interference ions, high homogeneous, better reproducibility etc. Base on these results, the various kinds of effect parameters were optimized. The ideal operation conditions are 1) methanol used as dissolving solvent; 2) sample first dropping method; 3) ratio between the analyte and matrix is 3.5:10. Under the optimization conditions, it gives low detection limit (0.1 fg for sucrose) and high reproducibility (≤29%). And the technique was successfully applied in analysis of low molecular saccharides and natural honey.

Keywords:Matrix;MALDI-TOF-MS;low molecules;honey;SBA-15

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