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Comparative quantification of microRNA in placenta and circulating nucleic acid isolated from maternal plasma and umbilical cord plasma
Yang Qi 1,Lu Jiafeng 1,Ge Qinyu 1 * #,Lu Zuhong 2
1.Southeast University
2.
*Correspondence author
#Submitted by
Subject:
Funding: Specialized Research Fund for the Doctoral Program of Higher Education（No.20070286029）
Opened online:18 August 2009
Accepted by: none
Citation: Yang Qi ,Lu Jiafeng ,Ge Qinyu.Comparative quantification of microRNA in placenta and circulating nucleic acid isolated from maternal plasma and umbilical cord plasma[OL]. [18 August 2009] http://en.paper.edu.cn/en_releasepaper/content/34515
 
 
The purpose of this study was to analyze the miRNA expression in placenta, maternal plasma and umbilical cord plasma of patients with mild and severe preeclampsia vs maternal plasma of normal pregnancies. Three families of miRNA was analyzed, which were miR-411, miR-154*and miR-18a. The miRNA expression was compared between mPE and sPE in the same kind of sample, and also among the three kinds of sample. The result showed that miR-411 and miR-154* was downexpressed and miR-18a was upexpressed. It also showed that the expression of miRNA in placenta was consistent with maternal plasma, but showed more significant change in maternal plasma of sPE vs mPE. However, the expression of miRNA in umbilical cord plasma showed no markable relationship with placenta and maternal plasma.
Keywords:microRNA;circuling nucleic acid;preeclampsia
 
 
 

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