Inhibition of cadmium-induced apoptosis by Glutathione S-transferase P1 via mitogen-activated protein kinases (MAPKs) and mitochondria

Chao Zhang; Weiping Mao; Xiuqin Kong; Ling Yue; Yanhong Gao; Zhimin Yin

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Inhibition of cadmium-induced apoptosis by Glutathione S-transferase P1 via mitogen-activated protein kinases (MAPKs) and mitochondria

Chao Zhang * #,Weiping Mao,Xiuqin Kong,Ling Yue,Yanhong Gao,Zhimin Yin

Jiangsu Province Key Laboratory for Molecular and Medicine Biotechnology, College of Life Science, Nanjing Normal University

*Correspondence author

#Submitted by

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Funding: none

Opened online: 4 March 2010

Accepted by: none

Citation: Chao Zhang,Weiping Mao,Xiuqin Kong.Inhibition of cadmium-induced apoptosis by Glutathione S-transferase P1 via mitogen-activated protein kinases (MAPKs) and mitochondria[OL]. [ 4 March 2010] http://en.paper.edu.cn/en_releasepaper/content/40427

Cadmium is a well-known toxic compound for the kidney. GSTP1 plays an important role in the detoxification and xenobiotics metabolism. We showed that in HEK 293 cells, hGSTP1-targeting RNAi reinforced apoptosis and the decrease in cell viability induced by Cd2+. Overexpression of GSTP1 diminished loss of mitochondrial membrane potential and cytochrome c release, inhibited MAPKs including ERK, JNK and p38, prevented caspase-3 activation and suppressed apoptosis induced by Cd2+. Oligonucleosomal DNA fragmentation demonstrated that adenovirus-mediated transfer of GSTP1 also prevented Cd2+-induced apoptosis in primary renal tubule cells. Our data suggest that GSTP1 is an inhibitor of Cd2+-induced apoptosis.

Keywords:Glutathione S-transferase P1;Cadmium toxicity;MAPKs;Mitochondria;primary renal tubule cells;Apoptosis

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