Transglutaminase 2: A Link between Periodontal Disease and Diabetes

Cui Cui; Mari T. Kaartinen; Liya Chen

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Transglutaminase 2: A Link between Periodontal Disease and Diabetes

Cui Cui 1,Mari T. Kaartinen 2,Liya Chen 3 *

1.School of Stomatology, Lanzhou University

2.Department of Medicine, McGill University

3.School of Stomatology, Lanzhou University

*Correspondence author

#Submitted by

Subject:

Funding: none

Opened online: 8 April 2010

Accepted by: none

Citation: Cui Cui,Mari T. Kaartinen,Liya Chen.Transglutaminase 2: A Link between Periodontal Disease and Diabetes[OL]. [ 8 April 2010] http://en.paper.edu.cn/en_releasepaper/content/41689

Diabetes is a prevalent metabolic disease with serious complications. Studies have proclaimed a bidirectional relationship between diabetes and periodontitis, the latter resulting from chronic inflammation of tooth-supporting structures with links to cardiovascular disease and premature births. The enzyme transglutaminase 2 (TG2) has biologic functions in insulin secretion and response, and it has recently been demonstrated to play a role in the pathogenesis of diabetes. TG2 activity influences inflammatory reactions and also wound healing, collagen deposition and bone formation. We hypothesize that changes in TG2 activity may be linked to the progression of both diseases, and thus manipulation of this activity could provide a new therapeutic route for treating periodontal disease in diabetic patients.

Keywords:Transglutanminase 2;Diabetes;Periodontitis

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