Home > Papers

 
 
Identification of β1,4-galactosyltransferase I As a target gene of Aflatoxin B1
Jiang Jianhai * #,Wei Yuanyan,Gu Jianxin
Key Laboratory of Glycoconjuates Research, Minitry of Public Health, Shanghai Medical College of Fudan University
*Correspondence author
#Submitted by
Subject:
Funding: 国家教委新教师博士点基金（No.NO. 20070246046）
Opened online:10 January 2011
Accepted by: none
Citation: Jiang Jianhai,Wei Yuanyan,Gu Jianxin.Identification of β1,4-galactosyltransferase I As a target gene of Aflatoxin B1[OL]. [10 January 2011] http://en.paper.edu.cn/en_releasepaper/content/4403552
 
 
Objective To investigae the effec of Aflatoxin B1 (AFB1) exposure, an etiological factors associated with hepatocellular carcinoma on the expression of β1,4-galactosyltransferase I. Methods Immunohistochemistry method was used to detect the expression of GalT I in hepatoma tissues and normal tissues. And, double luciferase reporter analysis was used to detect the effect of Aflatoxin B1 on GalT promoter activity. Results β1,4-galactosyltransferase I (GalT I) is significantly up-regulated in hepatoma, and is transcriptionally regulated by AFB1. The AFB1-induced GalT I transcription is mediacted by E2F1 transcription factor. Conclusions These results provide genetic evidence that GalT I upregulation mediated by E2F1 might contribute to hepatoma development mediated by AFB1.
Keywords:The glycobioogy of tumor;Hepatoma;Aflatoxin B1;β1,4-galactosyltransferase I
 
 
 

For this paper
  • ● PDF (0B)
  • ● Revision 0 　　
  • ● Print this paper
  • ● Recommend this paper to a friend
  • ● Add to my favorite list

    Saved Papers

    Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags
Add yours

Related Papers

Statistics
PDF Downloaded 225
Bookmarked 0
Recommend 5
Comments Array
Submit your papers