Expression and sub-cellular localization of leucine-rich repeats and immunoglobulin-like domain 1 is related to antioxidant enzymes in human ependymoma and oligodendroglioma

YI Wei; LIU Lin; OKECHI Humphrey; CHEN Qianxue; HUANG Shulan

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Expression and sub-cellular localization of leucine-rich repeats and immunoglobulin-like domain 1 is related to antioxidant enzymes in human ependymoma and oligodendroglioma

YI Wei 1 * #,LIU Lin 2,OKECHI Humphrey 3,CHEN Qianxue 3,HUANG Shulan 3

1.Department of Neurosurgery,Renmin Hospital of Wuhan University

2.Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

3.Department of Neurosurgery, Renmin Hospital of Wuhan University

*Correspondence author

#Submitted by

Subject:

Funding: the North Sweden Cancer Foundation, the Specialized Research Fund for the Doctoral Program New Teacher of Higher Education by the Chinese Ministr（No.No. 200804861039）, the Swedish Institute （No.No. 00287/2006210）, the National Natural Science Foundation of China （No.No. 30973073 & 30973072）

Opened online: 2 June 2011

Accepted by: none

Citation: YI Wei,LIU Lin,OKECHI Humphrey.Expression and sub-cellular localization of leucine-rich repeats and immunoglobulin-like domain 1 is related to antioxidant enzymes in human ependymoma and oligodendroglioma[OL]. [ 2 June 2011] http://en.paper.edu.cn/en_releasepaper/content/4429431

The current study investigated correlations between the expression of leucine-rich repeats and immunoglobulin-like domain 1 (LRIG1) and antioxidant enzymes and related proteins, including manganese superoxide dismutase, glutamate cysteine ligase catalytic or regulatory subunit, thioredoxin and thioredoxin reductase, in both human ependymoma and oligodendroglioma. Results revealed that the cytoplasmic expression of LRIG1 was associated with expression of glutamate cysteine ligase catalytic subunit in the human ependymoma, while the nuclear expression of LRIG1 was associated with expression of thioredoxin reductase. In human oligodendroglioma, the cytoplasmic expression of LRIG1 was associated with expression of the glutamate cysteine ligase catalytic subunit. Both the nuclear and perinuclear expressions of LRIG1 were associated with expression of glutamate cysteine ligase regulatory subunit. These results indicated that several antioxidant enzymes and related proteins contributed to LRIG1 expression, and that these may participate in the antioxidation of the cells.

Keywords:leucine-rich repeats and immunoglobulin-like domain 1; sub-cellular localization; ependymoma; oligodendroglioma; antioxidant enzymes

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