In vivo experiments of laser induced interstitial thermotherapy on liver tissue with FBG temperature distribution sensor

CHEN Na; CHEN Shaofeng; ZHU Hongfei; LIU Shupeng; CHEN Zhenyi

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In vivo experiments of laser induced interstitial thermotherapy on liver tissue with FBG temperature distribution sensor

CHEN Na 1 * #,CHEN Shaofeng 2,ZHU Hongfei 2,LIU Shupeng 2,CHEN Zhenyi 2

1.The Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai University

2.The Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai University, Shanghai 200072

*Correspondence author

#Submitted by

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Funding: Research Fund for the Doctoral Program of Higher Education Ministry of Education of China （No.No. 20093108120017）

Opened online:20 October 2011

Accepted by: none

Citation: CHEN Na,CHEN Shaofeng,ZHU Hongfei.In vivo experiments of laser induced interstitial thermotherapy on liver tissue with FBG temperature distribution sensor[OL]. [20 October 2011] http://en.paper.edu.cn/en_releasepaper/content/4445508

In this paper, we measured the temperature distribution of liver tissue both in vivo and in vitro during Laser Induced Interstitial Thermotherapy (LITT). Fiber Bragg grating (FBG) was embedded in the laser irradiated bio tissues used as fully distributed temperature sensor. The temperature profile was reconstructed from its reflection spectra. The temperature measurement system we built can measure the FBG axial temperature distribution. We studied the dependence of the temperature distribution and laser output power experimentally and compared the results of in vivo and in vitro under similar laser irradiating conditions. Experimental results show that the slope and trend of the measured temperature curves in vivo and in vitro are almost identical. Due to influence of body temperature, the in vivo measured temperature is higher than the in vitro one with an almost constant temperature difference value.

Keywords:FBG; temperature distribution measurement; in vivo; in vitro; liver tissue; LITT

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