Pro-apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells

DING Hui; SHI Dahua; LI Erguang; WANG Yurong; JIANG Chunping; WU Junhua

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Pro-apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells

DING Hui 1,SHI Dahua 2,LI Erguang 2,WANG Yurong 2,JIANG Chunping 2,WU Junhua 2 * #

1.Jiangsu Key Laboratory of Molecular Medicine, State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, NanJing 210093

2.Jiangsu Key Laboratory of Molecular Medicine, State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University

*Correspondence author

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Funding: Funds of Guangdong Province （No.2007B090400109）, the Science Foundation of Ministry of Health of China （No.No. LW201008）, the Natural Science Foundation of Jiangsu Province （No.No. BK2009010 and BK2008267）, the National Natural Science Foundation of China （No.No. NSFC30801417）, Specialized Research Fund for the Doctoral Program of Higher Education （No.No. SRFDP200802841004）

Opened online: 9 February 2012

Accepted by: none

Citation: DING Hui,SHI Dahua,LI Erguang.Pro-apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells[OL]. [ 9 February 2012] http://en.paper.edu.cn/en_releasepaper/content/4461207

Tectorigenin, a main isoflavone in the Iris tectorum rhizome which was used traditionally for treating liver-related diseases, was shown to inhibit the growth of human hepatoma HepG2 cells, and to induce the cell apoptosis. In the apoptotic process, the intracellular ROS and Ca2+ elevation acted as an early event followed by depolarization of mitochondrial membrane potential (MMP). And then cytochrome c was released to cytosol. Moreover, the tectorigenin treatment co-enhanced the caspase-3, -8 and -9 proteolytic activities. In conclusion, tectorigenin significantly inhibited the proliferation and induced apoptosis in human hepatocellular carcinoma HepG2 cells mainly via mitochondrial-mediated pathway. And the death receptor-dependent pathway might play a certain role in the apoptotic process. These observations indicated that tectorigenin is the active principle of Iris tectorum rhizome applied in the folk medicine for alleviating liver disorders, and that the isoflavone is a promising candidate for hepatocellular carcinoma chemotherapeutic and chemopreventive agent.

Keywords:Tectorigenin; Anti-proliferation; Apoptosis; Mitochondrial; HepG2

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