Preparation and characterization of novel pH-sensitive N-succinyl-chitosan/poly(vinyl alcohol) hydrogel

FAN Lihong; WEN Feng; WU Penghui; WANG Libo; TAN Chang; SHA Mingming

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Preparation and characterization of novel pH-sensitive N-succinyl-chitosan/poly(vinyl alcohol) hydrogel

FAN Lihong * #,WEN Feng,WU Penghui,WANG Libo,TAN Chang,SHA Mingming

College of Chemical Engieering, Wuhan University of Technology, WuHan 430070

*Correspondence author

#Submitted by

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Funding: none

Opened online: 8 February 2012

Accepted by: none

Citation: FAN Lihong,WEN Feng,WU Penghui.Preparation and characterization of novel pH-sensitive N-succinyl-chitosan/poly(vinyl alcohol) hydrogel[OL]. [ 8 February 2012] http://en.paper.edu.cn/en_releasepaper/content/4462334

Blended hydrogels have been widely used in biomedical fields due to their biocompatibility and biodegradability. In order to get a new kind of blended hydrogel using as deliver system for drugs, we prepared N-succinyl-chitosan (NSCS) and Poly (vinyl alcohol) blended hydrogels by freezing-thawing method. The hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy. Antibacterial activity of hydrogels composite within nanosilver was also investigated. The swelling degree of hydrogels was increased with the amount of NSCS. Protein release studies were performed in different pH solutions. The results showed that the release rate was slower under acid than under basic conditions, which could be attributed to the pH-sensitive of NSCS. It is suggesting that the NSCS/PVA hydrogels could be potentially applied as oral delivery systems for protein drugs.

Keywords:Pharmacy; Hydrogel; N-succinyl-chitosan; Poly (vinyl alcohol); Protein release

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