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Hypoglycemic and hypolipidemic effect of polyphenols from burs of Castanea mollissima Blume
Yin Peipei 1,Zhao Shan 2,Siyu Chen 2,Jieyuan Liu, 2,Lingling Shi 2,Liu Yujun 2 *,Ma Chao 2
1.National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Biotechnology,Beijing Forestry University, Beijing 100083
2.National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Biotechnology,Beijing Forestry University, Beijing 100083, China
*Correspondence author
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Funding: Ph.D. Programs Foundation of Ministry of Education of China (No.20100014120017), Central Universities, China (No.BLYX200922)
Opened online:31 March 2012
Accepted by: none
Citation: Yin Peipei,Zhao Shan,Siyu Chen.Hypoglycemic and hypolipidemic effect of polyphenols from burs of Castanea mollissima Blume[OL]. [31 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4473103
 
 
Substantial evidence suggests that phenolic extracts of Castanea mollissima Spiny burs(CMPE)increase pancreatic cell viability after STZ (streptozotocin) treatment as a result of their antioxidant properties. In the present study, the hypoglycemic and hypolipidemic activities of CMPE were studied in normal and STZ-induced diabetic rats. CMPE were orally administrated at dose of 150 and 300 mg/kg twice a day for 12 consecutive days. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels, malondialdehyde (MDA) level and SOD activity in liver, kidney, spleen and heart tissues were spectrophotometrically measured. In normal rats, no significant changes were observed in serum glucose, lipid profiles and tissue MDA and GSH levels after orally administration of CMPE. In diabetic rats, orally administration of CMPE at dose of 300 mg/kg caused significant decrease in serum glucose, triglyceride, total cholesterol, LDL-cholesterol levels, as well as MDA and GSH levels in spleen and liver tissues. However, dosage of 300 mg/kg caused a significant body weight lose in both normal and diabetic rats. The observed effects indicated that CMPE could be further developed as potential compounds to prevent abnormal changes in blood glucose and lipid profile and to attenuate lipid peroxidation in liver and spleen tissues.
Keywords:Castanea mollissima; tannins; polyphenols; diabetes; hypoglycemic; hypolipidemic; chestnut burs
 
 
 

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