Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodeling after myocardial infarction

Liu Yi; Ye Xiaoying; Mao Lina; Cheng Zhaokang; Yao Xinpeng; Jia Xiaohua; Mao Duo; Ou Lailiang; Li Zongjin; Che Yongzhe; Liu Na; Liu Lin; Kong Deling

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Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodeling after myocardial infarction

Liu Yi 1 #,Ye Xiaoying 2,Mao Lina 3,Cheng Zhaokang 2,Yao Xinpeng 2,Jia Xiaohua 2,Mao Duo 2,Ou Lailiang 2,Li Zongjin 4,Che Yongzhe 5,Liu Na 2,Liu Lin 2,Kong Deling 3 *

1.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, TianJin 300071

2.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071

3.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Biomedical Engineering, Tianjin 300192

4.Medical School of Nankai Univeristy, Tianjin 300071

5.Medical School of Nankai University, Tianjin 300071

*Correspondence author

#Submitted by

Subject:

Funding: Doctoral Fund of Ministry of Education of China （No.20090031110024）

Opened online:21 December 2012

Accepted by: none

Citation: Liu Yi,Ye Xiaoying,Mao Lina.Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodeling after myocardial infarction[OL]. [21 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4504322

Aims: Parthenogenetic embryonic stem cells (pESCs) are derived from artificially activated oocytes without fertilization and therefore raise minimal ethical concerns and may serve as attractive candidates for regenerative medicine. We thought to investigate whether pESCs can repair myocardial infarction (MI). Methods and Results: Mice (n=89) survived coronary ligation randomly received undifferentiated pESCs, ESCs, or saline. Sham-operated mice received no treatment (n=21). After 7 days, pESCs transplantation promoted pro-angiogenic factors secretion and reduced infiltrated leukocytes. pESCs-treated hearts, superior to ESC group, showed prevented cardiac remodeling and enhanced angiogenesis in and 30 days post MI. Heart contractile function was notably improved by administration of pESCs by 30 days. Moreover, tissues regenerated from the engrafted pESCs in the infarcted myocardium were positive for cardiomyocyte, endothelial cell and smooth muscle cell markers. Furthermore, teratoma fomation appeared in ESCs-treated mice in high proportion (6/34), but surprisingly not found in pESCs-treated mice (0/30) by 30 days. Conclusions: Cardiac dysfunction and adverse ventricular remodeling post MI were attenuated by pESCs transplantation, which may represent an effective and relatively safer strategy for autologous cell therapy in females.

Keywords:Parthenogenetic stem cells; embryonic stem cell; myocardial infarction; teratoma; stem cell therapy

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