Prognostic value of circulating DNA in HCC patients underwent liver transplantation

Hu Jie; Wang Zheng; Fan Jia; Zhou Jian

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Prognostic value of circulating DNA in HCC patients underwent liver transplantation

Hu Jie 1 #,Wang Zheng 2,Fan Jia 2,Zhou Jian 2 *

1.Liver Cancer Institution, Zhongshan Hospital, Fudan University, ShangHai 200032

2.Liver Cancer Institution, Zhongshan Hospital, Fudan University

*Correspondence author

#Submitted by

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Funding: Research Fund for the Doctoral Program of Higher Education of China（No.20090071110022）

Opened online:27 February 2013

Accepted by: none

Citation: Hu Jie,Wang Zheng,Fan Jia.Prognostic value of circulating DNA in HCC patients underwent liver transplantation[OL]. [27 February 2013] http://en.paper.edu.cn/en_releasepaper/content/4521474

Genetic variations play an important role in tumor development and metastasis. Oligonucleotide microarrays were used to evaluate the genetic characteristics of tumor DNA in 30 HCC patients who were underwent LT. Recurrence-related single-nucleotide polymorphism were selected, and their prognostic value was assessed and validated in two independent cohorts of HCC patients, using pretransplant plasma circulating DNA. Prognostic significance was assessed by Kaplan-Meier survival estimates and log-rank tests. rs894151 and rs12438080 were significantly associated with recurrence (P=.003 and P=.004, respectively). Multivariate analyses demonstrated that the co-index of the 2 SNPs was an independent prognostic factor for recurrence (P=.040). Similar results were obtained in the third cohort (N=77). Furthermore, for HCC patients exceeding Milan criteria, the co-index was a prognostic factor for recurrence and survival (P<.001 and P=.002, respectively). Our study demonstrated first that genetic variations of rs894151 and rs12438080 in pretransplant plasma circulating DNA are promising prognostic markers for tumor recurrence in HCC patients undergoing LT.

Keywords:hepatocellular carcinoma; liver transplantation; circulating DNA; prognosis

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