The noncoding RNA Llme23 drives the malignant property of human melanoma cells

Wu Chuanfang; tanguanghong; machengchuan; liling

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The noncoding RNA Llme23 drives the malignant property of human melanoma cells

Wu Chuanfang 1 #,tanguanghong 2,machengchuan 3,liling 3 *

1.sichuan university, college of life science, ChengDu 610065

2.Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College

3.sichuan university, college of life science

*Correspondence author

#Submitted by

Subject:

Funding: Ph.D. Programs Foundation of the Ministry of Education of China（No.Grant 20090181120076）, This work was supported by National Natural Science Foundation of China（No.Grants 31000579 and 30971634）, Provincial Natural Science Foundation of Hainan of China（No.Grant 310045）

Opened online: 5 March 2013

Accepted by: none

Citation: Wu Chuanfang,tanguanghong,machengchuan.The noncoding RNA Llme23 drives the malignant property of human melanoma cells[OL]. [ 5 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4522449

Several lines of evidence support the notion that increased RNA-binding ability of Polypyrimidine tract-binding (PTB) protein-associated splicing factor (PSF) and aberrant expression of long noncoding RNAs (lncRNAs) are associated with mouse and human tumors. To identify the PSF-binding lncRNA involved in human oncogenesis, we screened a nuclear RNA repertoire of human melanoma line, YUSAC, through RNA-SELEX affinity chromatography. A previously unreported lncRNA, termed as Llme23, was found to bind immobilized PSF resin. The specific binding of Llme23 to both recombinant and native PSF protein was confirmed in vitro and in vivo. The expression of PSF-binding Llme23 is exclusively detected in human melanoma lines. Knocking down Llme23 remarkably suppressed the malignant property of YUSAC cells, accompanied by the repressed expression of proto-oncogene Rab23. These results may indicate that Llme23 can function as an oncogenic RNA and directly associate the PSF-binding lncRNA to human melanoma.

Keywords:LncRNA; Llme23; PSF; melanoma; Rab23

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