6-Hydroxydopamine Promotes Iron Traffic in Primary Cultured Astrocytes

ZHANG Haoyun; SONG Ning; XU Huamin; SHI Limin; JIANG Hong; XIE Junxia

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6-Hydroxydopamine Promotes Iron Traffic in Primary Cultured Astrocytes

ZHANG Haoyun 1,SONG Ning 2,XU Huamin 2,SHI Limin 2,JIANG Hong 2,XIE Junxia 2 *

1.Department of Physiology, Medical College of Qingdao University, ShanDong QingDao 266071

2.Department of Physiology, Medical College of Qingdao University

*Correspondence author

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Funding: National Program of Basic Research sponsored by the Ministry of Science and Technology of China （No.2011CB504102, 2012CB526703）, the National Nature Science Foundation of China（No.30930036）, the Department of Science and Technology of Shandong Province（No.ZR2012HZ005）

Opened online:13 March 2013

Accepted by: none

Citation: ZHANG Haoyun,SONG Ning,XU Huamin.6-Hydroxydopamine Promotes Iron Traffic in Primary Cultured Astrocytes[OL]. [13 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4527136

It is well known that disrupted brain iron homeostasis was involved in Parkinson's disease (PD). Astrocytes, the major glial cell type in the central nervous system, are largely responsible for iron distribution in the brain. However, how iron metabolism changes of astrocytes in PD are not fully elucidated. In the present study, we first observed that both iron influx and efflux were enhanced with 10 μM 6-OHDA treatment for 24 hrs in primary cultured astrocytes. In accordance with this iron traffic modulations, iron importer divalent metal transporter 1 with iron responsive element (DMT1+IRE) and exporter ferroportin 1 (FPN1) were up-regulated in these cells. Iron regulatory protein 1 (IRP1) showed a dynamic regulation with 6-OHDA treatment, as indicated by a moderate up-regulation at 12 hrs, however, down-regulation at 24 hrs. These results suggest that 6-OHDA might promote iron transport rate in astocytes by regulating iron transporters and IRP1 expression.

Keywords:Parkinson's disease; astrocytes; iron; iron transport; oxidative stress

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