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| With superoxide dismutase(SOD), catalase(CAT), alkaline phosphatase(AKP), acid phosphatase(ACP), malondialdehyde(MDA) and Bax protein expression as characteristic indexes, the effects of dibutyl phthalate(DBP) on ovarian active substance of mice were studied, and the toxic mechanisms were discussed. One hundred sixty mice were given intragastric administration of DBP (0, 100, 250, or 500 mg/(kgod)), respectively, for 30 days. At 5, 10, 20, 30 days after DBP exposure, the ovarian examinations were taken. The results revealed that administration of DBP decreased the activities of SOD, CAT, AKP and ACP, while MDA content and Bax protein expression increased. Two-way analysis of variance indicated that dose contributed more to DBP-induced ovarian damage than treatment time. The present study demonstrated that DBP promoted apoptosis and inhibited antioxidant capacity of the ovarian. |
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| Keywords:Dibutyl phthalate(DBP); Ovarian; Antioxidant capacity; Bax protein; Mice |
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