Design,synthesis and biological evaluation of novel asymmetric monocarbonyl analogues of curcumin (MACs ) as anti-inflammatory agents

ZHANG Yali; ZOU Peng; ZHAO Chengguang; LIANG Guang; YANG Shulin

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Design,synthesis and biological evaluation of novel asymmetric monocarbonyl analogues of curcumin (MACs ) as anti-inflammatory agents

ZHANG Yali 1,ZOU Peng 1,ZHAO Chengguang 1,LIANG Guang 2,YANG Shulin 1 *

1.Institute of Biotechnology, Nanjing University of Science and Technology, Nanjing 210094

2. School of Pharmacy, Wenzhou Medical College, Wenzhou 325035

*Correspondence author

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Funding: The Ministry of Education of China Foundation （No.No. 20093219110013）, Training Grant （No.No. 201210288053）

Opened online:15 March 2013

Accepted by: none

Citation: ZHANG Yali,ZOU Peng,ZHAO Chengguang.Design,synthesis and biological evaluation of novel asymmetric monocarbonyl analogues of curcumin (MACs ) as anti-inflammatory agents[OL]. [15 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4528456

In the past several years, a lot of symmetric mono-carbonyl analogues of curcumin (MACs) have been designed and synthesized in our laboratory. In the recent study, Eleven asymmetric MACs were designed and synthesized. Their bioactivities were evaluated by inhibit LPS-stimulated macrophages release proinflammation cytokines TNF-α and IL-6. The compound 1d exhibit the most inhibit activity among the test compounds. These data show that asymmetric MACs might serve as potential agents for the treatment of inflammatory diseases.

Keywords:Monocarbonyl analogues of curcumin (MACs); Synthesis; Macrophages; Anti-inflammation

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