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Tetracyclic Xanthone Derivatives via One-Pot Cascade Reaction
YU Fuchao 1 #,ZHANG Qianqian 2,ZHANG Yichuan 2,YAN Shengjiao 1,LIN Jun 1 *
1.Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, KunMing 650091
2.Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, KunMing 650091
*Correspondence author
#Submitted by
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Funding: We are grateful to the Specialized Research Fund for the Doctoral Program of Higher Education (No.No 2010531110003)
Opened online:15 May 2013
Accepted by: none
Citation: YU Fuchao,ZHANG Qianqian,ZHANG Yichuan.Tetracyclic Xanthone Derivatives via One-Pot Cascade Reaction[OL]. [15 May 2013] http://en.paper.edu.cn/en_releasepaper/content/4541813
 
 
A procedure for the synthesis of highly functional tetracyclic xanthone derivatives is described. A concise and efficient one-pot synthesis of structurally diverse tetracyclic xanthones was constructed by treating different types of heterocyclic ketene aminals with 3-formylchromone using catalytic Et3N in acetone at room temperature. The advantages of this method include high efficiency, mild reaction conditions and environmentally benign reagents. These xanthones are promising candidates for drug discovery. Consequently, a library of diverse tetracyclic xanthones was rapidly constructed using the present protocol and this concise process presented herein has great potential to be applied to parallel synthesis in drug discovery.
Keywords:tetracyclic xanthone; one-pot; cascade reaction; heterocyclic ketene aminals; 3-formylchromone
 
 
 

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