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Steroid receptor coactivator-3 promotes osteosarcoma progression through upregulation of FoxM1
GENG Shuo 1 #,WANG Xiaoyu 1,XU Xiaoyan 1,ZHANG Hepeng 1,MA Yan 1,ZHANG Yunqi 1,LI Baoxin 2,BI Zhenggang 1,YANG Chenglin 1 *
1.Department of Orthopedic Surgery, the First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng St., Nangang District, Harbin, Heilongjiang Prov.150001 China
2.Department of Pharmacology, Harbin Medical University, No. 194 Xuefu Road, Harbin, Heilongjiang Prov. 150081, China
*Correspondence author
#Submitted by
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Funding: Research Funds for the Returnees of Education Department of Heilongjiang Province of China （No.1253HQ003）, National Natural Science Foundation of China （No.81271984）, Natural Science Foundation for Returnees of Heilongjiang Province of China （No.LC2012C11）, Research Fund of the First Affiliated Hospital of Harbin Medical University （No.2013LX01）, Research Fund for the Doctoral Program of Higher Education of China （No.20122307120036）
Opened online:25 December 2013
Accepted by: none
Citation: GENG Shuo,WANG Xiaoyu,XU Xiaoyan.Steroid receptor coactivator-3 promotes osteosarcoma progression through upregulation of FoxM1[OL]. [25 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4571958
 
 
In this Increasing evidence suggest that the three homologous members of steroid receptor coactivator (SRC) family (SRC-1, SRC-2 and SRC-3) play key roles in enhancing cell proliferation in various human cancers, such as breast, prostate and hepatocellular carcinoma. However, the function of SRC-3 in osteosarcoma remains largely unexplored. In the current study, we found that SRC-3, but not SRC-1 and SRC-2, was dramatically up-regulated in human osteosarcoma tissues, compared with adjacent normal tissues. To explore the functions of SRC-3 in osteosarcoma, in vitro studies were performed in MG63 and U2OS cells. SRC-3 overexpression promoted osteosarcoma cells proliferation whereas knockdown of SRC-3 inhibits its proliferation. In support of these findings, we further demonstrated that SRC-3 up-regulated FoxM1 expression through co-activation of C/EBP. Together, our results show that SRC-3 drives osteosarcoma progression and imply it as a therapeutic target to abrogate osteosarcoma.
Keywords:Surgery 1; Osteosarcoma 2; Transcription 3; SRC-3 4; FoxM1 5; C/EBP? 6;
 
 
 

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