Antiplatelet Profiles of Six Water Extracts from Medicinal Herbs for Activating Blood and Resolving Stasis

TAO Li; ZHANG Lei; RUAN Junshan; YAN Linggeng; LU Yin

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Antiplatelet Profiles of Six Water Extracts from Medicinal Herbs for Activating Blood and Resolving Stasis

TAO Li 1 #,ZHANG Lei 1,RUAN Junshan 1,YAN Linggeng 1,LU Yin 2 *

1.College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023

2.Jiangsu Key Laboratory for Pharmacology and safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023

*Correspondence author

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Funding: The National Key Technology R&D Program （No.No. 2008BAI51B02）, Ph.D. Programs Foundation of Ministry of Education of China （No.No. 20113237110008). Jiangsu College graduate research and innovation projects）, This work was supported by the National Natural Science Foundation of China （No.No. 81173174 and 81202655）

Opened online:13 December 2013

Accepted by: none

Citation: TAO Li,ZHANG Lei,RUAN Junshan.Antiplatelet Profiles of Six Water Extracts from Medicinal Herbs for Activating Blood and Resolving Stasis[OL]. [13 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4573339

Traditional Chinese medicine (TCM) for activating blood and resolving stasis (Huoxuehuayu) has been widely applied in treatment of various platelet-related diseases. The present study was to explore the antiplatelet activity of the water extracts from six kinds of Huoxuehuayu herbs commonly used in clinical context, which fall into three categories, namely Hexue, Huoxue, and Poxue. We also investigated the differences in the antiplatelet activity of the water extracts from three categories. To this end, human platelet aggregation assay induced by ADP and thrombin was used to evaluate the antiplatelet activity, and flow cytometry assay for detecting the effects on the expression of CD41 and CD62P, two activated platelet surface markers. Results showed that all the water extracts (1 mg/ml) could significantly suppress human platelet aggregation in vitro (P<0.01), but extracts from three categories exhibited different inhibitory effects on expression of CD41 and CD62P respectively, suggesting the different properties for Huoxuehuayu. We concluded that combined use of Huoxuehuayu herbs may have potent therapeutic effects against platelet-related diseases in clinical contexts.

Keywords:Platelet aggregation; CD41, CD62P; Huoxuehuayu TCM; Water extracts

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