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The clinical impact of SYT-SSX fusion gene and other prognostic factors in synovial sarcoma
Ren Tingting #,Lu Qunshan,Guo Wei *
Musculoskeletal Tumor Center, Peking University People’s Hospital
*Correspondence author
#Submitted by
Subject:
Funding: National Natural Science Foundation of China （No.Grant No.81001193)，the Specialized Research Fund for the Doctoral Program of Higher Education of China）
Opened online:24 December 2013
Accepted by: none
Citation: Ren Tingting,Lu Qunshan,Guo Wei.The clinical impact of SYT-SSX fusion gene and other prognostic factors in synovial sarcoma[OL]. [24 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4575580
 
 
Background The aim of this study is to evaluate distribution and clinical impact of the SS18-SSX fusion gene in patients with synovial sarcoma in China. Methods We collected and analyzed the clinical data of 88 patients using univariate and multivariate survival analysis. HEK 293T and NIH 3T3 cell lines were transfected with the SS18-SSX1 or SS18-SSX2 gene to determine the respective involvement of these fusion genes in cell proliferation and invasiveness. Results Overall survival was significantly better among SS18-SSX2 cases (P=0.001), FNCLCC grade 2 cases (P<0.001), and UICC stage 1 or 2 (P<0.001) by univariate and multivariate survival analysis. SS18-SSX1-positive cells were more proliferative and invasive than SS18-SSX2-positive cells. Conclusion SS18-SSX fusion type is a significant prognostic factor for patients with synovial sarcoma
Keywords:Synovial sarcoma; SS18-SSX 1; SS18-SSX 2; survival analysis
 
 
 

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