Selective bromination of toluidines and cresols with N-bromosuccinimide

Fang Xubin; Fang Lei

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Selective bromination of toluidines and cresols with N-bromosuccinimide

Fang Xubin,Fang Lei *

School of chemistry and chemical engineering, Southeast University, 210009

*Correspondence author

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Funding: none

Opened online:26 December 2013

Accepted by: none

Citation: Fang Xubin,Fang Lei.Selective bromination of toluidines and cresols with N-bromosuccinimide[OL]. [26 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4576050

Using N-bromosuccinimide (NBS) as a convenientbromine source, bromination of toluidine and cresols was studied systematically to clarify the underlying mechanism and the orientation effect. Based on this methodology, several potential AChE inhibtors i.e. 3-bromo-2-methoxy-5-methyl-9H-carbazole, 3,6-dibromo-2-meth-oxy-5- methyl- 9H-carbazole, and 5-(bromomethyl)- 2-methoxy-9-(phenylsulfonyl)carbazole were synthesized.

Keywords:Medicinal Chemistry; Bromination; N-bromosuccinimide; Toluidine; Cresol

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